依主持人姓氏筆畫序排列 *主持人欄位之括弧( )內所示為NHRI合作執行人。 自105年度起，為鼓勵院內、外學術合作，若有與NHRI研究人員實質合作提出研究計畫申請者，經審查通過，NHRI合作執行人將獲得NHRI院內配合款補助。惟，各申請案無論是否有NHRI研究人員參與皆不影響審查，其審查標準一致為所提 研究計畫是否 符合徵求之研究重點及其科學價值。
| 計畫名稱 Title of Application | 執行機構 Applicant Organization | *主持人/(NHRI合作執行人) P.I. Name/(NHRI Researcher) | 計畫型態 Type of Application |
|---|---|---|---|
| 新穎的CDK5標靶結合PARP抑制劑合併療法可克服PARP抗藥性機制 The Mechanism of CDK5-mediated Resistance to PARP Inhibitors and the Development of Combination Therapy and Biomarkers to Overcome It |
中國醫藥大學 China Medical University |
山口浩史 Yamaguchi, Hirohito |
IRG |
| 以隨機對照試驗評估藥師衛教計畫對於心房纖維顫動病人之服藥順從性以及治療效果之影響 Impact of A Pharmacist-Led Education Program on Medication Adherence and Treatment Effectiveness of Direct Oral Anticoagulants in Patients with Atrial Fibrillation: A Randomized Control Trial |
國立臺灣大學 National Taiwan University |
王繼娟 Wang, Chi-Chuan |
IRG |
| 人類血小板裂解物對中樞神經系統之白質損傷的保護作用 Protective Effects of Human Platelet Lysates on CNS White Matter Damages |
臺北醫學大學 Taipei Medical University |
白台瑞 Burnouf, Thierry P. R. |
IRG |
| 端粒核糖核酸介導的表觀遺傳與誘發細胞質內的免疫反應對於老化機制的影響 TERRA-mediated epigenetic regulation and TERRA R-loop induced cytosolic immune response underlie human aging (A) Specific Aims |
國立臺灣大學 National Taiwan University |
朱雪萍 Chu, Hsueh-Ping |
IRG |
| 以人工智慧強化之動脈波型監測器導引心肺復甦時的最佳胸部按壓位置 Utilizing Artificial Intelligence to Optimize Chest Compression Region during Cardiopulmonary Resuscitation for Patients with Outof- hospital Cardiac Arrest (AIR-CPR) |
醫療財團法人徐元智先生醫藥基金會亞東紀念醫院 Far Eastern Memorial Hospital |
朱聖恩 Chu, Sheng-En |
IRG |
| 以分子工程彈頭殲滅受病毒感染的蚊子 Engineered Molecular Warheads Target Virus-Infected Mosquitoes |
國立臺灣大學 National Taiwan University |
余明俊 Yu, Ming-Jiun |
IRG |
| 利用整合之多組體學探討普遍存在於冠狀病毒之八核苷酸保守序列之分子生物學及評估用於抗病毒藥物設計之新穎標靶 Unveiling the molecular biology of the universally conserved coronavirus octamer and evaluating the novel targets for antiviral designs by multi-omics integration |
國立中興大學 National Chung Hsing University |
吳弘毅 Wu, Hung-Yi |
IRG |
| 探討台灣成人心血管-腎臟-代謝症候群的盛行趨勢與風險因素控制及其與社會決定因素的關聯 Trends in the Prevalence and Risk Factor Control of Cardiovascular-Kidney-Metabolic Syndrome in Relation to Social Determinants of Health among Taiwanese Adults |
醫療財團法人徐元智先生醫藥基金會亞東紀念醫院 Far Eastern Memorial Hospital |
吳泓彥 Wu, Hon-Yen |
IRG |
| 大氣粒狀污染物組成成份與新生兒健康以及死亡風險之探討：與NASA MAIA團隊之國際合作 Ambient Speciated Airborne Particulate Matter on Birth Outcomes and Mortality: Collaboration with the MAIA Team of NASA |
國立成功大學 National Cheng Kung University |
李佩珍 Lee, Pei-Chen |
IRG |
| 開發蛋白激酶Cδ標靶治療於EGFR TKI抗藥性肺癌之機轉與應用 Development of Protein Kinase C Delta (PKCδ) Target Therapy for EGFR TKI-resistant Lung Cancer |
中國醫藥大學 China Medical University |
李培志 Lee, Pei-Chih |
IRG |
| 機器學習應用於臺灣身心共病、多重用藥、高需求、高成本病人 Machine Learning for Physical-Mental Multimorbidity, Polypharmacy, High-Needs High-Costs Patients in Taiwan |
國立臺灣大學 National Taiwan University |
李達宇 Lee, Ta-Yu |
IRG |
| 運用中孔洞二氧化矽奈米載體傳遞PBX1抑制劑克服吉西他濱所誘導抗藥性胰臟癌之癌幹細胞特性 Application of PBX1 Inhibitors Derived from Mesoporous Silica Nanoparticles to Overcome the Cancer Stem Cell Properties Induced by Gemcitabine in Chemoresistant Pancreatic Cancer Cells |
臺北醫學大學 Taipei Medical University |
沈耀安 Shen, Yao-An |
IRG |
| 以個人化網路之機器學習模型構建數位分身用於預測頭頸癌患者的抗癌藥物療效 Personalized Network-based Machine Learning Model Builds Digital Twins for Predicting Anti-cancer Drug Efficacy in Head and Neck Cancer Patients |
國立陽明交通大學 National Yang Ming Chiao Tung University |
林峻宇 Lin, Chun-Yu |
IRG |
| O連結乙醯葡萄氨糖修飾於B1 細胞之功能及其對癌症進程影響之研究 Functional Role of O-GlcNAcylation in B1 Cells and Its Involvement in Cancer Progression |
中央研究院 Academia Sinica |
林國儀 Lin, Kuo-I |
IRG |
| 解構游離脂肪酸受體在腸道與神經系統中於巴金森氏症之致病機制與治療標的之潛力 Investigating the pathogenic mechanisms and potential therapeutic targets of free fatty acid receptors in the crosstalk between the gut and nervous systems in Parkinson’s disease |
國立臺灣大學 National Taiwan University |
林靜嫻 Lin, Chin-Hsien |
IRG |
| E3 泛素連接酶在重新編程腫瘤相關巨噬細胞代謝、極化和功能中所扮演的角色 Reprogramming the metabolism, polarization and function of tumor-associated macrophages by E3 ubiquitin ligases |
國立臺灣大學 National Taiwan University |
柯俊榮 Ko, Chun-Jung |
IRG |
| 利用噴霧乾燥技術開發無賦形劑的Bedaquiline與Pyrazinamide吸入型粉末作為潛在的結核病治療方案 Developing Excipient-Free Inhalable Powders of Bedaquiline and Pyrazinamide Using Spray Drying for Potential Treatment of Tuberculosis |
國立臺灣大學 National Taiwan University |
柯威任 Ke, Wei-Ren |
CDG |
| 透過飲食誘導的 NAFLD 動物模型揭示兒童非酒精性脂肪肝 (NAFLD) 的分子機制 Unraveling the Molecular Mechanisms of Non-Alcoholic Fatty Liver Disease (NAFLD) in Children Through a Diet-Induced NAFLD Animal Model |
中央研究院 Academia Sinica |
胡春美 Hu, Chun-Mei |
IRG |
| 探討單次與多次叢集性磁刺激術作用小腦在成人自閉症的效應 Explore the Impacts of One Session and Multiple Session Theta Burst Stimulation Over Cerebellum in Adults with Autism Spectrum Disorder |
長庚醫療財團法人 Chang Gung Medical Foundation |
倪信章 Ni, Hsing-Chang |
CDG |
| 脂質從腫瘤相關的巨噬細胞直接轉移到腫瘤細胞在透明細胞腎細胞癌的進展中的重要性 Direct transfer of lipids from the tumor-associated macrophages to tumor cells in the progression of clear-cell renal cell carcinoma |
中國醫藥大學 China Medical University |
徐沺 Hsu, Tien |
IRG |
| 探索YAP與TAZ在腫瘤免疫反應中的相異功能 Deciphering the Differential Roles of YAP and TAZ in Tumor Immunity |
國立陽明交通大學 National Yang Ming Chiao Tung University |
袁維謙 Yuan, Wei-Chien |
CDG |
| 策略訓練促進體能活動對中風後認知損傷患者的執行功能的影響：第二期隨機分配試驗 Effects of Strategy Training for Physical Activity on Executive Functions in Stroke Survivors with Cognitive Impairments: A Phase II Randomized Controlled Trial |
臺北醫學大學 Taipei Medical University |
張鳳航 Chang, Feng-Hang |
IRG |
| 解碼早期蟹足腫傷口癒合中促纖維化纖維細胞與發炎細胞之間的分子對話 Deciphering the Molecular Crosstalk between Profibrotic Fibroblasts and Inflammatory Cells in Early Keloid Wound Healing |
國立成功大學 National Cheng Kung University |
許釗凱/(黃道揚) Hsu, Chao-Kai/(Hwang, Daw-Yang) |
IRG |
| 探討海馬齒狀迴中CCK中間神經元的角色：對大麻素影響迴路、認知與情緒的含義 Investigating the Role of CCK Interneurons in the Dentate Gyrus: Implications for Cannabinoid Effects on the Circuitry, Cognition, and Emotion |
國立陽明交通大學 National Yang Ming Chiao Tung University |
連正章 Lien, Cheng-Chang |
IRG |
| 甲基化表觀基因體延緩退化性關節炎機轉研究：巨噬細胞外泌體分子調節軟骨細胞粒線體代謝 Methyl Epigenome Repression of Osteoarthritis: Macrophage Extracellular Vesicle Action to Cartilage |
長庚醫療財團法人 Chang Gung Medical Foundation |
連韋雄 Lian, Wei-Shiung |
IRG |
| 新時代的舊把戲: 以抗雌激素優化荷爾蒙陽性乳癌免疫治療之機轉研究 Old Trick in the New Era:A Mechanistic Study of Anti-estrogen to Optimize Immunotherapy in Hormone Receptor Positive Breast Cancer |
國立臺灣大學醫學院附設醫院癌醫中心分院 National Taiwan University Cancer Center |
陳怡君 Chen, I-Chun |
CDG |
| 藉由對p53 引發DNA 損傷的單細胞層級研究來控制癌症細胞的非遺傳異質性 Single-cell Investigation of p53-induced DNA Damage for the Control of Non-genetic Heterogeneity in Cancer Cells |
中央研究院 Academia Sinica |
陳昇宏 Chen, Sheng-Hong |
IRG |
| 深入探討EB 病毒溶裂期基因產物對細胞區室 (compartment)造成的影響以作為對抗相關疾病標的 Deciphering EBV Lytic Gene Products-induced Cellular Compartment Reorganization to Combat EBV Associated Diseases |
國立臺灣大學 National Taiwan University |
陳美如 Chen, Mei-Ru |
IRG |
| 標靶腫瘤巨噬細胞奈米粒子用於胰臟癌免疫治療 Nanoparticle Delivery Systems to Target and Reprogram Tumor-Associated Macrophages For Cancer Immunotherapy |
國立清華大學 National Tsing Hua University |
陳韻晶/(林淑宜) Chen, Yun-Ching/(Lin, Shu-Yi) |
IRG |
| 超音波超高解析度微血管造影用於評估經導管動脈微栓塞治療手指和手腕慢性肌肉骨骼疼痛治療效果 Ultrasound Super Resolution Microvascular Imaging for Evaluating the Treatment Performance of Transcatheter Arterial Microembolization in Chronic Musculoskeletal (MSK) Pain of Finger and Wrist. |
國立成功大學 National Cheng Kung University |
黃執中 Huang, Chih-Chung |
IRG |
| 解碼大腦印記體的新機轉及功能: 提供精神及神經疾病的新治療策略 Decoding novel mechanisms and functions of brain imprintome: applications to mental and neurological disorders |
國立臺灣大學 National Taiwan University |
黃憲松 Huang, Hsien-Sung |
IRG |
| 運用非傳統環狀RNA的創新登革次單位疫苗候選物 Innovative Dengue Subunit Vaccine Candidates Using Unconventional Circular RNAs |
國立成功大學 National Cheng Kung University |
萬書彣/(余佳益) Wan, Shu-Wen/(Yu, Chia-Yi) |
IRG |
| 整合代謝基因調控機轉與合成基因電路載體在神經內分泌前列腺癌免疫治療的應用 Integrating Metabolic Gene Regulatory Network with Synthetic Gene Circuit for Neuroendocrine Prostate Cancer Immunotherapy |
臺北醫學大學 Taipei Medical University |
劉晏年 Liu, Yen-Nien |
IRG |
| 探討新中心體蛋白引發平腦症與小腦症相關神經發育疾病之致病機轉 Investigating the Functional Roles of Novel Centrosomal Proteins Associated with Lissencephaly- and Microcephaly-Related Neurodevelopmental Disorders |
國立陽明交通大學 National Yang Ming Chiao Tung University |
蔡金吾 Tsai, Jin-Wu |
IRG |
| 阻斷葉酸代謝能維持心肌細胞染色體的雙倍性以幫助心臟再生 Blockage of Folate Metabolism Maintains Diploidy in Adult Cardiomyocyte for Heart Regeneration |
臺北醫學大學 Taipei Medical University |
鄭媛元 Cheng, Yuan-Yuan |
CDG |
| 安非他命類興奮劑於多巴胺系統之神經化學研究：連結基因腦造影學與基因神經病理學 The Neurochemistry of Dopamine Systems in Amphetamines: Bridging Imaging Genetics with Genetic Neuropathology |
國立成功大學醫學院附設醫院 National Cheng Kung University Hospital |
魏士郁/(林彥鋒) Wei, Shyh-Yuh/(Lin, Yen-Feng) |
CDG |
| 用於憂鬱症治療的進階個人化腦波導引大腦刺激技術之開發 Development of Advanced Personalized EEG-Guided Brain Stimulation for Depression |
國立陽明交通大學 National Yang Ming Chiao Tung University |
魏群樹 Wei, Chun-Shu |
CDG |
| 促進胰臟癌之硼中子捕獲治療:發展刺激反應性多功能硼奈米藥物 Advancing Boron Neutron Capture Therapy for Pancreatic Cancer: Development of stimuli-Responsive and Multifunctional Boron Nanodrugs |
國立清華大學 National Tsing Hua University |
龔佩雲 Keng, Pei-Yuin |
IRG |