依主持人姓氏筆畫序排列 *主持人欄位之括弧( )內所示為NHRI合作執行人。 自105年度起，為鼓勵院內、外學術合作，若有與NHRI研究人員實質合作提出研究計畫申請者，經審查通過，NHRI合作執行人將獲得NHRI院內配合款補助。惟，各申請案無論是否有NHRI研究人員參與皆不影響審查，其審查標準一致為所提研究計畫是否符合徵求之研究重點及其科學價值。
| 計畫名稱 Title of Application | 執行機構 Applicant Organization | *主持人/(NHRI合作執行人) P.I. Name/(NHRI Researcher) | 計畫類型 Type of Application |
|---|---|---|---|
| 以細胞能量代謝為標靶之神經保護策略：粒線體功能障礙小鼠模式之研究 Targeting Cellular Energy Metabolism for Neuroprotection in a Mouse Model of Mitochondrial Dysfunction | 長庚醫療財團法人 Chang Gung Medical Foundation | 王南凱 Wang, Nan-Kai | IRG |
| 探討RACK7/KDM5C H3K4 去甲基酵素複合體在乳癌免疫治療的免疫調節作用 Investigation of the Immunomodulatory Role of RACK7/KDM5C H3K4 Demethylase Complex in Breast Cancer Immunotherapy | 中央研究院 Academia Sinica | 王書品 Wang, Shu-Ping | IRG |
| 開發針對創傷後壓力症候群之神經行為障礙的創新治療策略：以飲食限制調控腸道菌相訊號之機制研究 Developing novel therapeutic strategies for post-traumatic stress disorder-related neurobehavioral dysregulation: targeting dietary restriction-regulated gut microbiota signaling | 國立臺灣大學 National Taiwan University | 王培育 Wang, Pei-Yu | IRG |
| 利用複製壓力誘發之先天免疫反應克服癌症治療抗性 Exploiting Replication Stress–Induced Innate Immunity to Overcome Therapeutic Resistance in Cancer | 中國醫藥大學 China Medical University | 王紹椿 Wang, Shao-Chun | IRG |
| 以轉錄體學解析腎細胞癌之致癌與惡性機制 Elucidating the Oncogenic and Malignant Mechanisms of Renal Cell Carcinoma Using Transcriptomic Approaches | 國立陽明交通大學 National Yang Ming Chiao Tung University | 王琬菁 Wang, Won-Jing | IRG |
| 嗜中性球LRRK2於真菌驅動腸道發炎中的角色與機制 Neutrophil LRRK2 in Fungal-Driven Intestinal Inflammation | 國立臺灣大學 National Taiwan University | 江皓森 Chiang, Hao-Sen | IRG |
| 總體基因體分析病毒種群庫和細菌原噬菌體激活抗病毒反應參與腸癌病變機制研究 Metagenomics Analysis of Virome Ecosystem and Antiviral Response to Bacterial Prophages in Intestinal Carcinogenesis | 國立臺灣大學 National Taiwan University | 余佳慧 Yu, Linda Chia-Hui | IRG |
| 無顯影劑腦瘤輔助診斷系統：從定量到可信賴視覺語言模型報告生成 Non-contrast Brain Tumor Computer-Aided Diagnosis System: From Quantification to Trustworthy Report Generation via Vision-Language Models | 國立陽明交通大學 National Yang Ming Chiao Tung University | 吳育德 Wu, Yu-Te | IRG |
| 基於人工智能之早產兒視網膜病變篩檢創新系統：多中心研究 Novel Artificial Intelligence-Based System for Retinopathy of Prematurity Screening: A Multi-Center Study | 長庚醫療財團法人 Chang Gung Medical Foundation | 吳為吉 Wu, Wei-Chi | IRG |
| 長鏈非編碼核糖核酸調控之肺腺癌轉移與中樞神經系統趨性的分子機轉研究及新型標靶治療的開發 Investigation of Molecular Mechanisms of Long Non-coding RNAs-mediated Metastasis and Central Nervous System Tropism and Development of Novel Targeted Therapeutics in Lung Adenocarcinoma | 國立成功大學 National Cheng Kung University | 呂佩融 Lu, Pei-Jung | IRG |
| 結合單細胞分析與 AI 輔助模型解析 MAC 肺病免疫失調機制與疾病易感性預測 Dissecting Immune Dysfunction in MAC Lung Disease through Single-Cell Profiling and AI-Assisted Susceptibility Prediction | 國立臺灣大學 National Taiwan University | 李孟叡 Lee, Meng-Rui | CDG |
| 探討阿卡替尼抑制 ABP1–肌動蛋白軸作為抑制病理性骨吸收之新穎治療策略 Acalabrutinib-mediated inhibition of the ABP1–actin axis as a novel therapeutic strategy to suppress pathological bone resorption | 國立臺灣大學 National Taiwan University | 李明學 Lee, Ming-Shyue | IRG |
| 全光學探查痛覺神經軸中的神經病理性疼痛 All-Optical Interrogation of Neuropathic Pain Along the Nociceptive Neuraxis | 中央研究院 Academia Sinica | 李國昇 Lee, Kuo Sheng | CDG |
| 透過 m-TRAP 顯示技術在整合微流體系統上篩選對 KIF2C 具有高親和力和高特異性的胜肽 Screening of peptides with high affinity and high specificity towards KIF2C on integrated microfluidic systems via m-TRAP display techniques | 國立清華大學 National Tsing Hua University | 李國賓 Lee, Gwo-Bin | IRG |
| 組蛋白 N 端乙醯酶 Naa40 與男性不孕之機制探討 Mechanistic Investigation of Histone N-alpha-acetyltransferase Naa40 in Male Infertility | 中央研究院 Academia Sinica | 阮麗蓉 Juan, Li-Jung | IRG |
| 探討CCL5訊號在創傷性腦損傷後神經修復過程中協調軸突再生和神經發生微環境重塑中的作用 Investigating the role of CCL5 signaling in coordinating axonal regeneration and neurogenic niche remodeling during neural repair after traumatic brain injury | 臺北醫學大學 Taipei Medical University | 周思怡 Chou, Szu-Yi | IRG |
| 慢性肢體威脅性缺血中使用秋水仙素以降低併發症與肢體事件之隨機分派試驗（CIRCLE-Asia 試驗） Colchicine in Chronic Limb-Threatening Ischemia for Reduction of Complications and Limb Events in Asia (CIRCLE-Asia trial) | 新光醫療財團法人新光吳火獅紀念醫院 Shin Kong Wu Ho-Su Memorial Hospital | 林姝含 Lin, Donna Shu-Han | CDG |
| 解析新穎銅調控機制促進腫瘤代謝重整之機轉與轉移性乳癌之精準治療 Dissecting a Novel Copper-Regulatory Mechanism Driving Metabolic Reprogramming for Precision Therapy of Metastatic Breast Cancer | 臺北醫學大學 Taipei Medical University | 林政緯 Lin, Cheng-Wei | IRG |
| 開發鎖定CD177的專一生物分子以探討CD177和CD177:PR3複合體如何調控人類嗜中性白血球之功能 Developing CD177-targeting biomolecules to investigate the roles of CD177 and CD177:proteinase 3 complex in modulating neutrophil function | 長庚大學 Chang Gung University | 林錫賢 Lin, Hsi-Hsien | IRG |
| 細胞凋亡誘導DUSP11降解對A型流感病毒複製的影響 Impact of Apoptosis-Induced DUSP11 Degradation on Influenza A Virus Replication | 長庚大學 Chang Gung University | 邱亞芳 Chiu, Ya Fang | IRG |
| 運用智慧運算輔助護理決策系統預防老年人術後譫妄之成效探討: 精準護理照護模式建置 Effects of a Smart Computing-Assisted Nursing Decision Support System in Preventing Postoperative Delirium in Older Adults: Establishment of a Precision Nursing Care Model | 臺北醫學大學 Taipei Medical University | 邱曉彥 Chiu, Hsiao-Yean | IRG |
| 利用人類多能幹細胞平台探討U2 snRNP介導之RNA剪接在大腦皮質演化及畸形發育之分子機轉 Delineating the evo-devo roles of U2 snRNP-mediated RNA splicing in cortical malformation using human iPSC-based models | 國立陽明交通大學 National Yang Ming Chiao Tung University | 侯珮珊 Hou, Pei-Shan | IRG |
| 環狀RNA作為microRNA海綿：工程化PEG10蛋白奈米顆粒用於可編程RNA包裝和肝癌治療 Circular RNA as a microRNA Sponge: Engineering PEG10 Protein Nanoparticles for Programmable RNA Packaging and Liver Cancer Therapy | 國立清華大學 National Tsing Hua University | 胡育誠/(福安) Hu, Yu-Chen/(Vu Anh Truong) | IRG |
| 術中快速免疫組織化學病理診斷系統之開發與臨床應用 Development and Clinical Application of an Intraoperative Rapid Immunohistochemical Pathology System | 國立臺灣大學 National Taiwan University | 孫啟光 Sun, Chi-Kuang | IRG |
| 自閉症和注意力不足過動症會提早老化嗎？長期追蹤多面向研究。 Do Autism and Attention Deficit Hyperactivity Disorder Lead to Premature Aging? A Longitudinal Multifaceted Study | 國立臺灣大學 National Taiwan University | 高淑芬 Gau, Susan Shur-Fen | IRG |
| 探討沙門氏菌基因毒素ADP-核糖基化活性作用機制與生理影響 Investigating the Mechanisms and Effects of ADP-Ribosylation Activity of a Salmonella Genotoxin | 國立臺灣大學 National Taiwan University | 張書蓉 Chang, Shu-Jung | IRG |
| 利用人源化酵母模型解析人類 SDHB 功能異常的機制與演化適應 Mechanistic and evolutionary dissection of human SDHB dysfunction using humanized yeast models | 臺北醫學大學 Taipei Medical University | 莊漢英 Jhuang, Han-Ying | IRG |
| 研究唾液外泌體膜蛋白與口腔癌關聯性並利用雙性粒子擴散儀實現早期快篩 Study of the Correlation Between Salivary Exosomal Membrane Proteins and Oral Cancer for Early Rapid Screening via Janus Particle Diffusometry | 國立成功大學 National Cheng Kung University | 莊漢聲 Chuang, Han-Sheng | IRG |
| RNA G-四股體與 PolyG 聚集複合體驅動之神經退化機制與治療策略 —以神經元核內包涵體疾病為例 Targeting Neuronal Intranuclear Inclusion Disease via G4-RNA and PolyG Aggregation Complex | 中央研究院 Academia Sinica | 陳俊安 Chen, Jun-An | IRG |
| 利用細胞球體組裝所驅動之許旺細胞修復機制重建神經免疫訊號並改善燒燙傷癒合 Leveraging Spheroid Assembly–Driven Schwann Cell Repair Programming to Restore Neuroimmune Signaling and Improve Burn Wound Healing | 長庚大學 Chang Gung University | 陳思恒 Chen, Shih Heng | CDG |
| 解析TRPML2介導之內溶小體離子訊號於髓系細胞功能與疾病中的角色 Decoding TRPML2-mediated endolysosomal ion signaling in myeloid cell function and disease | 國立臺灣大學 National Taiwan University | 陳政彰 Chen, Cheng-Chang | IRG |
| 利用CAR-T細胞針對FAP陽性纖維母細胞樣滑膜細胞：難治性類風濕性關節炎的潛在治療方法 Targeting FAP-Positive Fibroblast-like Synoviocytes with CAR-T Cells: A Potential Therapeutic Approach for Refractory Rheumatoid Arthritis | 長庚醫療財團法人 Chang Gung Medical Foundation | 曾文逸 Tseng, Wen-Yi | IRG |
| 孕期個人化飲食介入對妊娠糖尿病與血糖指標的影響：三組平行隨機對照試驗 Impact of Personalized Dietary Intervention during Pregnancy on Gestational Diabetes and Glycemic Parameters: A Three-Arm Parallel Group Randomized Controlled Trial | 國立臺灣大學 National Taiwan University | 曾翎威 Chen, Ling-Wei | IRG |
| 解構難治型憂鬱症之臨床軌跡與多體學特性 Trajectory Mapping and Multi-Omic Dissection of Treatment-Resistant Depression | 國立臺灣大學 National Taiwan University | 馮嬿臻 Feng, Yen-Chen | CDG |
| 最佳化中風後上肢遠距復健：TeleGRASP 劑量比較之隨機對照試驗 Optimizing upper extremity telerehabilitation after stroke: A dose-comparison trial of teleGRASP | 長庚大學 Chang Gung University | 楊婕淩 Yang, Chieh-Ling | IRG |
| 以幹性耦合基因依賴性模型解析高風險腫瘤分群及鑑定癌症生物標誌與治療標靶 A Stemness-Coupled Essentiality Framework for Stratification of High-Risk Tumors and Identification of Cancer Biomarkers and Therapeutic Targets | 國立陽明交通大學 National Yang Ming Chiao Tung University | 楊進木 Yang, Jinn-Moon | IRG |
| 尼曼匹克症 A 型（酸性神經鞘磷脂酶缺乏）中神經元－膠質細胞代謝耦合機制之探討 Investigating neuron-glia metabolic coupling in Niemann Pick disease type A/acidic sphingomyelinase deficiency | 國立臺灣大學 National Taiwan University | 詹智強 Chan, Chih-Chiang | IRG |
| 超音波增強化學栓塞結合人工淋巴結介導之原位CAR-T/NK編程於肝細胞癌之應用 Ultrasound-Enhanced Chemoembolization Coupled with Artificial Lymph Node–Mediated In situ CAR-T/NK Programming for Hepatocellular Carcinoma | 中國醫藥大學 China Medical University | 劉彥良 Liu, Yen-Liang | IRG |
| GSK3a於代謝壓力下經由整合應激反應(ISR)對 beta 細胞的保護 Protection of Beta-Cells via GSK3a-mediated Integrated Stress Response under Metabolic Stress | 國立臺灣大學 National Taiwan University | 劉雅雯 Liu, Ya-Wen | IRG |
| TLK2在大腸癌抗藥性產生的機制之探討 Investigating the functional role of TLK2 in colon cancer drug resistance | 國立中正大學 National Chung Cheng University | 蔡少正 Tsai, Shaw-Jenq Sean | IRG |
| 以整合性功能基因體學分析腫瘤內在調控γδ T細胞抗癌活性的關鍵因子 Integrative functional genomics analysis of tumor-intrinsic regulators of γδ T cell–mediated cytotoxicity | 國立臺灣大學 National Taiwan University | 蔡幸真 Tsai, Hsing-Chen | IRG |
| 非結核分枝桿菌肺病的宿主腸肺軸失衡: 從造成原因、腸道菌外泌體影響到可能益 生菌開發 Gut-lung axis imbalance in nontuberculous mycobacterial lung disease: studying the responsible causes, the impact by gut bacterial exosome, and the potential of probiotics development | 國立臺灣大學 National Taiwan University | 樹金忠 Shu, Chin-Chung | IRG |
| 解析粒線體脂肪酸氧化對肺泡上皮免疫反應之層級化調控機制 Unravel the hierarchical regulatory mechanisms of mitochondrial fatty acid oxidation in alveolar epithelial immunity | 國立臺灣大學 National Taiwan University | 鐘桂彬 Chung, Kuei-Pin | IRG |